Chatterjee Lab
The Programmable Biology Group
We integrate generative AI and experimental protein design to create
programmable platforms for genome, proteome, and cell engineering.
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Our Research
Programmable Genome Editing
Our mission is to enable CRISPR-mediated editing of any DNA sequence -- to cure genetic diseases, grow better crops, develop new bioenergy solutions, and enhance scientific applications of genome editing. To do this, we employ diverse computational methods, such as bioinformatics, machine learning, and structure-based modeling, to engineer robust Cas9 enzymes. Our current set of enzymes, including ScCas9, Sc++, iSpyMac, and now SpRYc, represent some of the broadest, safest, and most effective RNA-guided genome editors, to date.
Our Team
We program biology to do what we want.
Assistant Professor of Biomedical Engineering
Assistant Professor of Computer Science
Assistant Professor of Biostatistics and Bioinformatics
MIT (SB '16, SM '18, PhD '20)
Co-Founder of Gameto, Inc.
Co-Founder of UbiquiTx, Inc.
Postdoctoral Fellow
PhD (Fudan '20)
PhD Student
SB (MIT '23)
PhD Student - Duke NUS
BS (UC Davis '20)
Undergraduate
Duke '25
Undergraduate
Duke '25
Undergraduate
Duke '25
PhD Student
BS (Georgia Tech '22)
PhD Student
BS (ECJTU '23)
Research Associate
MS (Kyoto U '23)
Undergraduate
Duke '26
Undergraduate
Duke '25
Undergraduate
Duke '25
PhD Student
BS (Duke '23)
Masters Student
BS (Duke Kunshan '23)
Undergraduate
Harvard '24
Undergraduate
UNC '24
Undergraduate
Duke '27
Undergraduate
Duke '27
Our Alumni
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Sabrina Koseki, BA (Wellesley '22) → Research Scientist at Novartis
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Kalyan Palepu, AB (Harvard '23) → ML Engineer at D.E. Shaw Research
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Garyk Brixi, AB (Harvard '23) → PhD Student at Stanford
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Emma Tysinger, SB (MIT '23) → M.Eng. Student at MIT
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Teodora Stan, (MIT '24)
Our Featured Progress
We introduce SaLT&PepPr, a protein language model that derives high-affinity peptides using only the sequence of an interacting partner. We fuse these peptides to E3 ubiquitin ligases to degrade diverse targets in cancer cells! Check out our new manuscript in Communications Biology!
Contact Us!
Feel free to reach out and
learn more about our work!
Center for Advanced Genomic Technologies
Fitzpatrick Center (CIEMAS), Room 2339A
101 Science Drive
Duke University
Durham, NC 27705