The Programmable Biology Group

We integrate algorithms and experiments to generate
programmable platforms for genome, proteome, and cell engineering.

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Our Research

 

Expansive Genome Editing

Our mission is to enable CRISPR-mediated editing of any DNA sequence -- to cure genetic diseases, grow better crops, develop new bioenergy solutions, and enhance scientific applications of genome editing. To do this, we employ diverse computational methods, such as bioinformatics, machine learning, and structure-based modeling, to engineer robust Cas9 enzymes. Our current set of enzymes, including ScCas9, Sc++, iSpyMac, represent some of the broadest, safest, and most effective RNA-guided genome editors, to date.

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Our Team

We program biology to do what we want.

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Assistant Professor of
Biomedical Engineering

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Postdoctoral Fellow

PhD, Fudan University

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Postdoctoral Fellow

PhD, VCU

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PhD Student

BS, Georgia Tech

PhD Student

BS, University of Kansas

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Masters Student

BS, UC Davis

Masters Student

BS, CU Denver

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Undergraduate
Harvard

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Undergraduate 
Harvard

Undergraduate 
Harvard

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Visiting PhD Student

SM, MIT

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Undergraduate

MIT

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Undergraduate

Duke

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Undergraduate

Duke

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Undergraduate

Duke

Our Featured Work

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Our Cut&CLIP pipeline leverages Facebook's ESM embeddings and OpenAI's CLIP contrastive text-image mapping architecture to design target-specific peptides, fuse them to E3 ubiquitin ligases, and degrade pathogenic proteins in human cells! 

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Join Us!

Feel free to reach out and

learn more about our work!

Center for Advanced Genomic Technologies
Fitzpatrick Center (CIEMAS), Room 2339A
101 Science Drive
Duke University
Durham, NC 27705

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