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The Programmable Biology Group

We integrate algorithms and experiments to generate
programmable platforms for genome, proteome, and cell engineering.

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Our Research

Home: Research

Expansive Genome Editing

Our mission is to enable CRISPR-mediated editing of any DNA sequence -- to cure genetic diseases, grow better crops, develop new bioenergy solutions, and enhance scientific applications of genome editing. To do this, we employ diverse computational methods, such as bioinformatics, machine learning, and structure-based modeling, to engineer robust Cas9 enzymes. Our current set of enzymes, including ScCas9, Sc++, iSpyMac, represent some of the broadest, safest, and most effective RNA-guided genome editors, to date.

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Home: Our Team

Our Team

We program biology to do what we want.

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Assistant Professor of Biomedical Engineering

Assistant Professor of Computer Science

Assistant Professor of Biostatistics and Bioinformatics

Duke University

Co-Founder of Gameto, Inc.

Co-Founder of UbiquiTx, Inc.

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Postdoctoral Fellow

PhD, Fudan University

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PhD Student

BS, Georgia Tech

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PhD Student

BS, University of Kansas

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Visiting PhD Student

SM, MIT

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Undergraduate
Harvard

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Undergraduate 
Harvard

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Undergraduate 
Harvard

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Undergraduate

Duke

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Undergraduate

Duke Kunshan

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Undergraduate

Duke

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Undergraduate

Duke

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Undergraduate

Duke

Our Featured Work

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In conjunction with the Church Lab at Harvard and our spinout company Gameto, we have created a living, fully human ovarian organoid that supports the maturation of an egg, develops follicles, and secretes sex hormones. Read about it at eLife!

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Contact Us!

Feel free to reach out and

learn more about our work!

Center for Advanced Genomic Technologies
Fitzpatrick Center (CIEMAS), Room 2339A
101 Science Drive
Duke University
Durham, NC 27705

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