Chatterjee Lab
The Programmable Biology Group
We integrate algorithms and experiments to generate
programmable platforms for genome, proteome, and cell engineering.
Our Research
Expansive Genome Editing
Our mission is to enable CRISPR-mediated editing of any DNA sequence -- to cure genetic diseases, grow better crops, develop new bioenergy solutions, and enhance scientific applications of genome editing. To do this, we employ diverse computational methods, such as bioinformatics, machine learning, and structure-based modeling, to engineer robust Cas9 enzymes. Our current set of enzymes, including ScCas9, Sc++, iSpyMac, represent some of the broadest, safest, and most effective RNA-guided genome editors, to date.
Our Team
We program biology to do what we want.
Assistant Professor of Biomedical Engineering
Assistant Professor of Computer Science
Duke University
Postdoctoral Fellow
PhD, Fudan University
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Postdoctoral Fellow
PhD, VCU
PhD Student
BS, Georgia Tech
PhD Student
BS, University of Kansas
Masters Student
BS, UC Davis
Masters Student
BS, CU Denver
Undergraduate
Harvard
Undergraduate
Harvard
Undergraduate
Duke
Undergraduate
MIT
Undergraduate
Duke
Undergraduate
Duke
Undergraduate
Duke Kunshan
Undergraduate
Harvard
Undergraduate
Duke
Visiting PhD Student
SM, MIT
Our Featured Work
Our Cut&CLIP pipeline leverages Facebook's ESM embeddings and OpenAI's CLIP contrastive text-image mapping architecture to design target-specific peptides, fuse them to E3 ubiquitin ligases, and degrade pathogenic proteins in human cells!
Contact Us!
Feel free to reach out and
learn more about our work!
Center for Advanced Genomic Technologies
Fitzpatrick Center (CIEMAS), Room 2339A
101 Science Drive
Duke University
Durham, NC 27705