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The Programmable Biology Group

We integrate generative AI and experimental protein design to create
programmable platforms for genome, proteome, and cell engineering.

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Our Research

Home: Research

Programmable Proteome Editing

We are developing peptide-guided protein therapeutics to target disordered and "undruggable" proteins. To accomplish this goal, we train generative language models, such as Cut&CLIP, SaLT&PepPrPepPrCLIP, and PepMLM, to de novo design "guide" peptide binders to any pathogenic protein without needing its structure, and subsequently link these binders to post-translational modification domains to edit the protein. Our current peptide-E3 ubiquitin ligase fusions represent a CRISPR-like approach for targeted protein degradation. But why stop there? Our goal is to define the engineering and delivery principles for truly programmable proteome editing outcomes, including degradation, phosphorylation, glycosylation, acetylation, and beyond.

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Home: Our Team

Our Team

We program biology to do what we want.

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Assistant Professor of Biomedical Engineering

Assistant Professor of Computer Science

Assistant Professor of Biostatistics and Bioinformatics

MIT (SB '16, SM '18, PhD '20)

Co-Founder of Gameto, Inc.

Co-Founder of UbiquiTx, Inc.

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Postdoctoral Fellow

PhD (Fudan '20)

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PhD Student

BS (ECJTU '23)

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Masters Student

BS (Duke Kunshan '23)

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Undergraduate

Duke '25

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Undergraduate

Duke '25

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PhD Student

BS (Georgia Tech '22)

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PhD Student

BS (UNC '24)

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Research Associate 
MS (Kyoto U '23)

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Undergraduate

Duke '25

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Undergraduate

Duke '27

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PhD Student

BS (Duke '23)

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PhD Student - Duke NUS

BS (UC Davis '20)

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Undergraduate

Duke '25

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Undergraduate

Duke '25

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Undergraduate

Duke '27

Our Alumni
 

Our Updates and Progress

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Alexander disease is an extremely rare pediatric genetic disease that is caused by mutations in the protein GFAP. The EndAxD Foundation has graciously gifted us $50,000 to develop degraders to GFAP. We are grateful for their generous support!

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Contact Us!

Feel free to reach out and

learn more about our work!

Center for Advanced Genomic Technologies
Fitzpatrick Center (CIEMAS), Room 2339A
101 Science Drive
Duke University
Durham, NC 27705

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