The Programmable Biology Group
We integrate algorithms and experiments to generate
programmable platforms for genome, proteome, and cell engineering.
Expansive Genome Editing
Our mission is to enable CRISPR-mediated editing of any DNA sequence -- to cure genetic diseases, grow better crops, develop new bioenergy solutions, and enhance scientific applications of genome editing. To do this, we employ diverse computational methods, such as bioinformatics, machine learning, and structure-based modeling, to engineer robust Cas9 enzymes. Our current set of enzymes, including ScCas9, Sc++, iSpyMac, and now SpRYc, represent some of the broadest, safest, and most effective RNA-guided genome editors, to date.
We program biology to do what we want.
Assistant Professor of Biomedical Engineering
Assistant Professor of Computer Science
Assistant Professor of Biostatistics and Bioinformatics
Co-Founder of Gameto, Inc.
Co-Founder of UbiquiTx, Inc.
PhD, Fudan University
BS, Georgia Tech
BS, University of Kansas
Our Featured Progress
Our lab is one of ten recipients of the 2022 Hartwell Individual Biomedical Research Award! We will receive $100,000 a year for the next three years to develop therapeutic degraders for the treatment of Ewing sarcoma. We thank The Hartwell Foundation for their support!
Feel free to reach out and
learn more about our work!
Center for Advanced Genomic Technologies
Fitzpatrick Center (CIEMAS), Room 2339A
101 Science Drive
Durham, NC 27705