top of page

The Programmable Biology Group

We integrate algorithms and experiments to generate
programmable platforms for genome, proteome, and cell engineering.

Untitled - 2022-02-25T184535.118.png

Our Research

Home: Research

Expansive Genome Editing

Our mission is to enable CRISPR-mediated editing of any DNA sequence -- to cure genetic diseases, grow better crops, develop new bioenergy solutions, and enhance scientific applications of genome editing. To do this, we employ diverse computational methods, such as bioinformatics, machine learning, and structure-based modeling, to engineer robust Cas9 enzymes. Our current set of enzymes, including ScCas9, Sc++, iSpyMac, and now SpRYc, represent some of the broadest, safest, and most effective RNA-guided genome editors, to date.

spryc.png
Home: Our Team

Our Team

We program biology to do what we want.

duke_headshot_edited.jpg

Assistant Professor of Biomedical Engineering

Assistant Professor of Computer Science

Assistant Professor of Biostatistics and Bioinformatics

Duke University

Co-Founder of Gameto, Inc.

Co-Founder of UbiquiTx, Inc.

Zhaolin photo for website.jpeg

Postdoctoral Fellow

PhD, Fudan University

lauren.png

PhD Student

BS, Georgia Tech

Yudistyra.jpeg

PhD Student

BS, University of Kansas

kalyan.jpeg

Undergraduate
Harvard

182766343_1160811287664997_9063381215525697997_n.jpeg

Undergraduate 
Harvard

garyk.jpeg

Undergraduate 
Harvard

sophie.jpg

Undergraduate

Duke

unnamed.jpeg

Undergraduate

Duke Kunshan

srikar.jpg

Undergraduate

Duke

344578076_975122040591712_2390510044899522978_n_edited.jpg

Undergraduate

Duke

Screenshot_2023-05-13-12-04-39-03_e39d2c7de19156b0683cd93e8735f348.jpg

Undergraduate

UNC

Our Featured Progress

The-Hartwell-Foundation.jpeg

Our lab is one of ten recipients of the 2022 Hartwell Individual Biomedical Research Award! We will receive $100,000 a year for the next three years to develop therapeutic degraders for the treatment of Ewing sarcoma. We thank The Hartwell Foundation for their support!

IMG_1882.jpg
duke_1.jpg

Contact Us!

Feel free to reach out and

learn more about our work!

Center for Advanced Genomic Technologies
Fitzpatrick Center (CIEMAS), Room 2339A
101 Science Drive
Duke University
Durham, NC 27705

  • Twitter
  • LinkedIn

Thanks for submitting!

Home: Contact
bottom of page